Research workbench
Mus musculus CEP120 third C2 domain (C2C)
Analyse Mus musculus CEP120 third C2 domain (C2C) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6EWP
- Type
- protein
- Length
- 504 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Centrosomal protein of 120 kda
- UniProt
- Q7TSG1
- Pockets
- 7 · best druggability 0.77
Structure
x-ray diffraction · 3 distinct chains · 11% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Centrosomal protein of 120 kda | protein | 166 | 11% helix, 51% strand | Q7TSG1 |
| B | Centrosomal protein of 120 kda | protein | 171 | 11% helix, 50% strand | Q7TSG1 |
| C | Centrosomal protein of 120 kda | protein | 167 | 11% helix, 51% strand | Q7TSG1 |
Ligands and binding sites
- P6G · Hexaethylene glycol · additive · chains A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1012 | 0.77 | 0.79 | 80 | P6G |
| 2 | 224 | 0.55 | 0.78 | 33 | empty |
| 3 | 96 | 0.46 | 0.80 | 21 | empty |
| 4 | 135 | 0.45 | 0.77 | 18 | empty |
| 5 | 102 | 0.37 | 0.75 | 26 | empty |
Interfaces
3 interfaces between chains.
- A–C · 975 Ų buried · 15 hydrogen bonds · protein-protein
- A–B · 658 Ų buried · 15 hydrogen bonds · protein-protein
- B–C · 164 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7TSG1
- Elsewhere: RCSB PDB 6EWP · PDBe 6EWP · UniProt Q7TSG1
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