Crystal structure the peptide-substrate-binding domain of human type II collagen prolyl 4-hydroxylase complexed with pro-pro-gly-pro-arg- gly-pro-pro-gly.

Structure

x-ray diffraction · 2 distinct chains · 67% helix, 0% strand (DSSP).

Ligands and binding sites

• SO4 · Sulfate ion · ion · 2 copies · chains A, C
• DMS · Dimethyl sulfoxide · additive · 3 copies · chains A, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–C · 444 Ų buried · 10 hydrogen bonds · protein-protein

Compared structures

• 6EVO · Crystal structure the peptide-substrate-binding domain of human type II collagen prolyl… · the same entry in another collection · chain A against A, TM-score 1.00
• O15460 · AlphaFold monomer V2.0 prediction for prolyl 4-hydroxylase subunit alpha-2 (O15460) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O15460
• Elsewhere: RCSB PDB 6EVO · PDBe 6EVO · UniProt O15460