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Crystal structure of E. COLI dexh-box NTPase hrpb

Analyse Crystal structure of E. COLI dexh-box NTPase hrpb in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6EUD
Type: protein
Length: 808 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ATP-dependent RNA helicase hrpb
EC: 3.6.4.13
UniProt: P37024
Pockets: 11 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ATP-dependent RNA helicase hrpb (EC 3.6.4.13)	protein	808	39% helix, 21% strand	P37024

Ligands and binding sites

EDO · 1,2-ethanediol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

11 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	860	0.78	0.81	80	empty
2	330	0.59	0.77	29	empty
3	124	0.56	0.84	18	empty
4	98	0.43	0.78	17	EDO
5	82	0.40	0.78	15	empty

Compared structures

6EUD · Crystal structure of E. coli DExH-box NTPase HrpB · the same entry in another collection · chain A against A, TM-score 1.00
P37024 · AlphaFold monomer V2.0 prediction for ATP-dependent RNA helicase hrpb (P37024) · a predicted model of the same protein · chain A against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P37024
Elsewhere: RCSB PDB 6EUD · PDBe 6EUD · UniProt P37024

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