Research workbench
Enterococcus faecalis fic protein (H111A) in complex with sulfate.
Analyse Enterococcus faecalis fic protein (H111A) in complex with sulfate. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6ERB
- Type
- protein
- Length
- 794 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fic family protein
- UniProt
- U6S0Y1
- Ligands
- SO4
- Pockets
- 10 · best druggability 0.85
Structure
x-ray diffraction · 2 distinct chains · 61% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D, C | Fic family protein | protein | 198 | 61% helix, 2% strand | U6S0Y1 |
| B | Fic family protein | protein | 200 | 61% helix, 2% strand | U6S0Y1 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 4 copies · chains A, D, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1136 | 0.85 | 0.86 | 92 | empty |
| 2 | 873 | 0.80 | 0.83 | 77 | SO4 |
| 3 | 971 | 0.75 | 0.78 | 79 | SO4 |
| 4 | 62 | 0.70 | 0.97 | 21 | empty |
| 5 | 59 | 0.69 | 0.96 | 20 | empty |
Interfaces
6 interfaces between chains.
- A–C · 662 Ų buried · 5 hydrogen bonds · protein-protein
- D–B · 654 Ų buried · 5 hydrogen bonds · protein-protein
- A–D · 433 Ų buried · 10 hydrogen bonds · protein-protein
- B–C · 413 Ų buried · 9 hydrogen bonds · protein-protein
- D–C · 264 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 6ERB · Enterococcus faecalis FIC protein (H111A) in complex with sulfate. · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt U6S0Y1
- Elsewhere: RCSB PDB 6ERB · PDBe 6ERB · UniProt U6S0Y1
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