Research workbench
Conformational dynamism for DNA interaction in salmonella typhimurium rcsb response regulator. S207C P212121
Analyse Conformational dynamism for DNA interaction in salmonella typhimurium rcsb… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6EO3
- Type
- protein
- Length
- 401 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcriptional regulatory protein rcsb
- UniProt
- P58663
- Ligands
- SO4
- Pockets
- 2 · best druggability 0.43
Structure
x-ray diffraction · 2 distinct chains · 54% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcriptional regulatory protein rcsb | protein | 204 | 53% helix, 15% strand | P58663 |
| B | Transcriptional regulatory protein rcsb | protein | 197 | 54% helix, 15% strand | P58663 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 65 | 0.43 | 0.81 | 14 | empty |
| 2 | 54 | 0.32 | 0.77 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 1565 Ų buried · 20 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6EO3 · Conformational dynamism for DNA interaction in Salmonella typhimurium RcsB response… · the same entry in another collection · chain A against A, TM-score 1.00
- P58663 · AlphaFold monomer V2.0 prediction for transcriptional regulatory protein rcsb (P58663) · a predicted model of the same protein · chain B against A, TM-score 0.79
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P58663
- Elsewhere: RCSB PDB 6EO3 · PDBe 6EO3 · UniProt P58663
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