Research workbench
Structure of S.AUREUS clpc in complex with meca
Analyse Structure of S.AUREUS clpc in complex with meca in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6EMW
- Type
- protein
- Length
- 5,070 residues
- Chains
- 42
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-dependent clp protease ATP-binding subunit; Class III stress response-related ATPase…
- UniProt
- A0A4V1GG18, A0A4P9AXU9, A0A0U1MEM2, W8U1E4, Q2YSD6, A0A077UK83
- Pockets
- 20 · best druggability 0.64
Structure
electron microscopy · 7 distinct chains · 0% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, G, M, S, Y, k | ATP-dependent clp protease ATP-binding subunit | protein | 82 | 0% helix, 0% strand | A0A4V1GG18 |
| B, H, N, T, Z, l | ATP-dependent clp protease ATP-binding subunit | protein | 210 | 0% helix, 0% strand | A0A4P9AXU9 |
| C, I, O, U, a, m | Class III stress response-related ATPase, aaa+ superfamily | protein | 55 | 0% helix, 0% strand | A0A0U1MEM2 |
| D, J, P, V, b, n | ATP-dependent clp protease ATP-binding subunit clpc | protein | 90 | 0% helix, 0% strand | W8U1E4 |
| E, K, Q, W, c, o | ATP-dependent clp protease ATP-binding subunit clpc | protein | 166 | 0% helix, 0% strand | Q2YSD6 |
| F, L, R, X, d, p | ATP-dependent clp protease ATP-binding subunit clpc | protein | 152 | 0% helix, 0% strand | Q2YSD6 |
| e, f, g, h, i, j | Adapter protein meca | protein | 90 | 0% helix, 0% strand | A0A077UK83 |
Pockets
20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 727 | 0.64 | 0.74 | 119 | empty |
| 2 | 688 | 0.62 | 0.72 | 110 | empty |
| 3 | 543 | 0.58 | 0.72 | 87 | empty |
| 4 | 516 | 0.58 | 0.73 | 111 | empty |
| 5 | 524 | 0.58 | 0.72 | 89 | empty |
Interfaces
51 interfaces between chains.
- F–e · 360 Ų buried · 0 hydrogen bonds · protein-protein
- N–T · 276 Ų buried · 0 hydrogen bonds · protein-protein
- H–M · 271 Ų buried · 0 hydrogen bonds · protein-protein
- L–f · 271 Ų buried · 0 hydrogen bonds · protein-protein
- Z–k · 246 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6EMW · Structure of S.aureus ClpC in complex with MecA · the same entry in another collection · chain K against K, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A4V1GG18
- Every structure of UniProt A0A4P9AXU9
- Every structure of UniProt A0A0U1MEM2
- Every structure of UniProt W8U1E4
- Every structure of UniProt Q2YSD6
- Every structure of UniProt A0A077UK83
- Elsewhere: RCSB PDB 6EMW · PDBe 6EMW · UniProt A0A4V1GG18 · UniProt A0A4P9AXU9 · UniProt A0A0U1MEM2 · UniProt W8U1E4 · UniProt Q2YSD6 · UniProt A0A077UK83
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