Research workbench
Structure of serum resistance associated protein from T. B. rhodesiense
Analyse Structure of serum resistance associated protein from T. B. rhodesiense in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6ELU
- Type
- protein
- Length
- 2,450 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Serum resistance associated; G10_3 heavy chain; G10_3 light chain
- UniProt
- Q8T309
- Pockets
- 20 · best druggability 0.78
Structure
x-ray diffraction · 6 distinct chains · 51% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Serum resistance associated | protein | 193 | 78% helix, 0% strand | Q8T309 |
| B, E, H, K | G10_3 heavy chain | protein | 222 | 7% helix, 50% strand | — |
| C, F, I, L | G10_3 light chain | protein | 217 | 6% helix, 54% strand | — |
| D | Serum resistance associated | protein | 161 | 79% helix, 0% strand | Q8T309 |
| G | Serum resistance associated | protein | 168 | 81% helix, 0% strand | Q8T309 |
| J | Serum resistance associated | protein | 172 | 80% helix, 0% strand | Q8T309 |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1043 | 0.78 | 0.80 | 110 | empty |
| 2 | 941 | 0.78 | 0.81 | 95 | empty |
| 3 | 531 | 0.61 | 0.74 | 55 | empty |
| 4 | 306 | 0.59 | 0.78 | 52 | empty |
| 5 | 393 | 0.56 | 0.74 | 48 | empty |
Interfaces
21 interfaces between chains.
- K–L · 1959 Ų buried · 14 hydrogen bonds · protein-protein
- H–I · 1936 Ų buried · 14 hydrogen bonds · protein-protein
- E–F · 1924 Ų buried · 16 hydrogen bonds · protein-protein
- B–C · 1923 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 577 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 20 disulfide (disulfide).
Compared structures
- 6ELU · Structure of Serum Resistance Associated protein from T. b. rhodesiense · the same entry in another collection · chain I against I, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8T309
- Elsewhere: RCSB PDB 6ELU · PDBe 6ELU · UniProt Q8T309
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.