Research workbench
Crystal structure of mammalian REV7 in complex with human REV3 second binding site
Analyse Crystal structure of mammalian REV7 in complex with human REV3 second binding… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6EKM
- Type
- protein
- Length
- 224 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitotic spindle assembly checkpoint protein MAD2B; DNA polymerase zeta catalytic subunit
- EC
- 2.7.7.7
- UniProt
- Q9D752, O60673
- Pockets
- 2 · best druggability 0.50
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitotic spindle assembly checkpoint protein MAD2B | protein | 199 | 39% helix, 29% strand | Q9D752 |
| B | DNA polymerase zeta catalytic subunit (EC 2.7.7.7) | protein | 25 | 36% helix, 24% strand | O60673 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 80 | 0.50 | 0.83 | 17 | empty |
| 2 | 68 | 0.34 | 0.77 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 1360 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 6EKM · Crystal structure of mammalian Rev7 in complex with human Rev3 second binding site · the same entry in another collection · chain A against A, TM-score 1.00
- Q9D752 · AlphaFold monomer V2.0 prediction for mitotic spindle assembly checkpoint protein MAD2B… · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9D752
- Every structure of UniProt O60673
- Elsewhere: RCSB PDB 6EKM · PDBe 6EKM · UniProt Q9D752 · UniProt O60673
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