Research workbench
Structure of a hyperthermostable carbonic anhydrase identified from an active hydrothermal vent chimney
Analyse Structure of a hyperthermostable carbonic anhydrase identified from an active… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6EKI
- Type
- protein
- Length
- 1,332 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Carbonic anhydrase
- EC
- 4.2.1.1
- Ligands
- ZN
- Pockets
- 11 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 18% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Carbonic anhydrase (EC 4.2.1.1) | protein | 222 | 18% helix, 39% strand | — |
Ligands and binding sites
- ZN · Zinc ion · metal · 6 copies · chains A, B, C, D, E, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 862 | 0.74 | 0.78 | 90 | empty |
| 2 | 50 | 0.72 | 1.00 | 16 | empty |
| 3 | 847 | 0.68 | 0.75 | 78 | empty |
| 4 | 580 | 0.68 | 0.78 | 59 | empty |
| 5 | 382 | 0.57 | 0.75 | 46 | empty |
Interfaces
7 interfaces between chains.
- B–F · 1044 Ų buried · 19 hydrogen bonds · protein-protein
- C–E · 1028 Ų buried · 16 hydrogen bonds · protein-protein
- A–C · 563 Ų buried · 16 hydrogen bonds · protein-protein
- B–D · 533 Ų buried · 15 hydrogen bonds · protein-protein
- A–D · 313 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 6EKI · Structure of a hyperthermostable carbonic anhydrase identified from an active… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6EKI · PDBe 6EKI
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.