The metal ion-dependent adhesion site (midas) of the ALPHAMBETA2 integrin mac-1 I-domain promiscuously and competitively binds multiple ligands in the regulation of leukocyte function

Structure

x-ray diffraction · 1 distinct chain.

Ligands and binding sites

• POL · N-propanol · additive · 4 copies · chains A
• PEG · Di(hydroxyethyl)ether · additive · 3 copies · chains D, A
• IMD · Imidazole · additive · 2 copies · chains D, A
• MES · 2-(N-morpholino)-ethanesulfonic acid · additive · 2 copies · chains D, A
• GOL · Glycerol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6EJX · The metal ion-dependent adhesion site (MIDAS) of the alphaMbeta2 integrin Mac-1 I-domain… · the same entry in another collection · chain D against D, TM-score 1.00
• O35930 · AlphaFold monomer V2.0 prediction for platelet glycoprotein ib alpha chain (O35930) · a predicted model of the same protein · chain D against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O35930
• Elsewhere: RCSB PDB 6EJX · PDBe 6EJX · UniProt O35930