Research workbench
The KLC2 tpr domain bound to the JIP3 leucine zipper domain
Analyse The KLC2 tpr domain bound to the JIP3 leucine zipper domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6EJN
- Type
- protein
- Length
- 659 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kinesin light chain 2; C-jun-amino-terminal kinase-interacting protein 3
- UniProt
- Q91YS4, Q9ESN9
- Pockets
- 8 · best druggability 0.49
Structure
x-ray diffraction · 4 distinct chains · 81% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Kinesin light chain 2 | protein | 271 | 77% helix, 0% strand | Q91YS4 |
| B | Kinesin light chain 2 | protein | 267 | 79% helix, 0% strand | Q91YS4 |
| C | C-jun-amino-terminal kinase-interacting protein 3 | protein | 60 | 97% helix, 0% strand | Q9ESN9 |
| D | C-jun-amino-terminal kinase-interacting protein 3 | protein | 61 | 93% helix, 0% strand | Q9ESN9 |
Pockets
8 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 187 | 0.49 | 0.76 | 36 | empty |
| 2 | 105 | 0.46 | 0.79 | 19 | empty |
| 3 | 127 | 0.45 | 0.77 | 13 | empty |
| 4 | 92 | 0.44 | 0.79 | 18 | empty |
| 5 | 93 | 0.44 | 0.79 | 12 | empty |
Interfaces
5 interfaces between chains.
- C–D · 1594 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 386 Ų buried · 1 hydrogen bond · protein-protein
- A–D · 385 Ų buried · 1 hydrogen bond · protein-protein
- A–C · 288 Ų buried · 8 hydrogen bonds · protein-protein
- B–D · 279 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 6EJN · The KLC2 TPR domain bound to the JIP3 leucine zipper domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q9ESN9 · AlphaFold monomer V2.0 prediction for C-jun-amino-terminal kinase- interacting protein 3… · a predicted model of the same protein · chain D against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q91YS4
- Every structure of UniProt Q9ESN9
- Elsewhere: RCSB PDB 6EJN · PDBe 6EJN · UniProt Q91YS4 · UniProt Q9ESN9
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