Research workbench
DYRK1A in complex with jwd-065
Analyse DYRK1A in complex with jwd-065 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6EIV
- Type
- protein
- Length
- 1,348 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A
- EC
- 2.7.12.1
- UniProt
- Q13627
- Ligands
- B6Q
- Pockets
- 13 · best druggability 0.86
Structure
x-ray diffraction · 4 distinct chains · 35% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) | protein | 342 | 36% helix, 18% strand | Q13627 |
| B | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) | protein | 340 | 36% helix, 18% strand | Q13627 |
| C | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) | protein | 333 | 35% helix, 16% strand | Q13627 |
| D | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) | protein | 333 | 35% helix, 18% strand | Q13627 |
Ligands and binding sites
- B6Q · ~{N}-[3-[[4-azanyl-2-[[4-(4-methylpiperazin-1-yl) phenyl]amino]-1,3-thiazol-5-yl]carbonyl]phenyl]propanamide · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1096 | 0.86 | 0.86 | 115 | empty |
| 2 | 968 | 0.84 | 0.85 | 93 | empty |
| 3 | 813 | 0.79 | 0.82 | 82 | B6Q |
| 4 | 1154 | 0.78 | 0.79 | 78 | B6Q |
| 5 | 525 | 0.76 | 0.83 | 65 | B6Q |
Interfaces
6 interfaces between chains.
- A–B · 1268 Ų buried · 14 hydrogen bonds · protein-protein
- C–D · 1199 Ų buried · 11 hydrogen bonds · protein-protein
- A–D · 949 Ų buried · 12 hydrogen bonds · protein-protein
- B–C · 722 Ų buried · 7 hydrogen bonds · protein-protein
- A–C · 36 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 4 modified, 1 disulfide (phosphorylation, disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13627
- Elsewhere: RCSB PDB 6EIV · PDBe 6EIV · UniProt Q13627
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