Research workbench
Scfv abvance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery
Analyse Scfv abvance: increasing our knowledge of antibody structural space to enable… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6EHY
- Type
- protein
- Length
- 456 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Scfv antibody fragment
- Pockets
- 4 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 7% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Scfv antibody fragment | protein | 228 | 7% helix, 51% strand | — |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 466 | 0.70 | 0.80 | 46 | empty |
| 2 | 654 | 0.68 | 0.76 | 63 | empty |
| 3 | 101 | 0.39 | 0.76 | 19 | empty |
| 4 | 61 | 0.30 | 0.75 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 810 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6EHY · scFv AbVance: increasing our knowledge of antibody structural space to enable faster and… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6EHY · PDBe 6EHY
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