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Crystal structure of SNX23 px domain

Analyse Crystal structure of SNX23 px domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6EE0
Type: protein
Length: 396 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Kinesin-like protein KIF16B
UniProt: Q96L93
Pockets: 5 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Kinesin-like protein KIF16B	protein	132	41% helix, 22% strand	Q96L93

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	960	0.80	0.82	86	empty
2	99	0.50	0.82	15	empty
3	108	0.41	0.76	18	empty
4	73	0.40	0.79	14	empty
5	78	0.38	0.77	12	empty

Interfaces

3 interfaces between chains.

A–B · 528 Å² buried · 3 hydrogen bonds · protein-protein
A–C · 483 Å² buried · 2 hydrogen bonds · protein-protein
B–C · 472 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

6EE0 · Crystal Structure of SNX23 PX domain · the same entry in another collection · chain A against A, TM-score 1.00
Q96L93 · AlphaFold monomer V2.0 prediction for kinesin-like protein KIF16B (Q96L93) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96L93
Elsewhere: RCSB PDB 6EE0 · PDBe 6EE0 · UniProt Q96L93

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