Research workbench
Structure of a BRCA2-DSS1-ssdna complex
Analyse Structure of a BRCA2-DSS1-ssdna complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1MJE
- Type
- protein + DNA
- Length
- 648 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5'-D(P*TP*TP*TP*TP*TP*T)-3'; Deleted in split HAND/SPLIT foot protein 1; Breast cancer 2
- UniProt
- P60896
- Pockets
- 10 · best druggability 0.59
Structure
x-ray diffraction · 3 distinct chains · 25% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | 5'-D(P*TP*TP*TP*TP*TP*T)-3' | dna | 6 | — | — |
| B | Deleted in split HAND/SPLIT foot protein 1 | protein | 42 | 10% helix, 7% strand | P60896 |
| A | Breast cancer 2 | protein | 600 | 26% helix, 23% strand | — |
Pockets
10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 259 | 0.59 | 0.79 | 36 | empty |
| 2 | 103 | 0.55 | 0.84 | 20 | empty |
| 3 | 54 | 0.51 | 0.87 | 23 | empty |
| 4 | 145 | 0.47 | 0.77 | 25 | empty |
| 5 | 116 | 0.40 | 0.76 | 22 | empty |
Interfaces
2 interfaces between chains.
- B–A · 2778 Ų buried · 28 hydrogen bonds · protein-protein
- C–A · 960 Ų buried · 11 hydrogen bonds · protein-nucleic
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P60896
- Elsewhere: RCSB PDB 1MJE · PDBe 1MJE · UniProt P60896
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