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Crystal structure of the nipah virus phosphoprotein multimerization domain G519N

Analyse Crystal structure of the nipah virus phosphoprotein multimerization domain G519N in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6EB8
Type: protein
Length: 811 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Phosphoprotein
UniProt: Q9IK91
Pockets: 8 · best druggability 0.69

Structure

x-ray diffraction · 5 distinct chains · 83% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Phosphoprotein	protein	104	83% helix, 0% strand	Q9IK91
E	Phosphoprotein	protein	103	87% helix, 0% strand	Q9IK91
D, H, F, G	Phosphoprotein	protein	101	83% helix, 0% strand	Q9IK91
C	Phosphoprotein	protein	100	81% helix, 0% strand	Q9IK91
B	Phosphoprotein	protein	100	80% helix, 0% strand	Q9IK91

Pockets

8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	836	0.69	0.75	69	empty
2	117	0.44	0.77	18	empty
3	93	0.40	0.77	13	empty
4	74	0.39	0.78	13	empty
5	79	0.39	0.78	13	empty

Interfaces

15 interfaces between chains.

E–F · 2636 Å² buried · 27 hydrogen bonds · protein-protein
D–C · 2598 Å² buried · 25 hydrogen bonds · protein-protein
H–G · 2590 Å² buried · 34 hydrogen bonds · protein-protein
A–B · 2563 Å² buried · 26 hydrogen bonds · protein-protein
A–D · 2502 Å² buried · 24 hydrogen bonds · protein-protein

Compared structures

6EB8 · Crystal Structure of the Nipah Virus Phosphoprotein Multimerization Domain G519N · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9IK91
Elsewhere: RCSB PDB 6EB8 · PDBe 6EB8 · UniProt Q9IK91

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