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The crystal structure of bovine ultralong antibody bov-6
Analyse The crystal structure of bovine ultralong antibody bov-6 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6E9Q
- Type
- protein
- Length
- 1,731 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bovine ultralong antibody bov-6 heavy chain; Bovine ultralong antibody bov-6 light chain
- UniProt
- Q3T101
- Pockets
- 20 · best druggability 0.69
Structure
x-ray diffraction · 7 distinct chains · 4% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Bovine ultralong antibody bov-6 heavy chain | protein | 229 | 4% helix, 51% strand | — |
| B, F | Bovine ultralong antibody bov-6 light chain | protein | 215 | 5% helix, 52% strand | Q3T101 |
| C | Bovine ultralong antibody bov-6 heavy chain | protein | 245 | 1% helix, 53% strand | — |
| D | Bovine ultralong antibody bov-6 light chain | protein | 214 | 7% helix, 49% strand | Q3T101 |
| E | Bovine ultralong antibody bov-6 heavy chain | protein | 224 | 4% helix, 54% strand | — |
| G | Bovine ultralong antibody bov-6 heavy chain | protein | 219 | 4% helix, 51% strand | — |
| H | Bovine ultralong antibody bov-6 light chain | protein | 170 | 5% helix, 39% strand | Q3T101 |
Pockets
20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 68 | 0.69 | 0.95 | 24 | empty |
| 2 | 760 | 0.66 | 0.75 | 94 | empty |
| 3 | 171 | 0.65 | 0.86 | 39 | empty |
| 4 | 320 | 0.62 | 0.79 | 33 | empty |
| 5 | 348 | 0.60 | 0.77 | 36 | empty |
Interfaces
11 interfaces between chains.
- C–D · 2051 Ų buried · 11 hydrogen bonds · protein-protein
- E–F · 2039 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 1993 Ų buried · 14 hydrogen bonds · protein-protein
- G–H · 1629 Ų buried · 4 hydrogen bonds · protein-protein
- B–D · 529 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 25 disulfide (disulfide).
Compared structures
- 6E9Q · The crystal structure of bovine ultralong antibody BOV-6 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q3T101
- Elsewhere: RCSB PDB 6E9Q · PDBe 6E9Q · UniProt Q3T101
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