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Crystal structure of the bacillus subtilis sliding clamp-mutl complex.

Analyse Crystal structure of the bacillus subtilis sliding clamp-mutl complex. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6E8D
Type: protein
Length: 1,816 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta sliding CLAMP,DNA mismatch repair protein mutl
UniProt: A0A085C685, A0A164SDM9
Pockets: 18 · best druggability 0.75

Structure

x-ray diffraction · 4 distinct chains · 23% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Beta sliding CLAMP,DNA mismatch repair protein mutl	protein	465	24% helix, 39% strand	A0A085C685, A0A164SDM9
B	Beta sliding CLAMP,DNA mismatch repair protein mutl	protein	458	23% helix, 40% strand	A0A085C685, A0A164SDM9
C	Beta sliding CLAMP,DNA mismatch repair protein mutl	protein	454	21% helix, 39% strand	A0A085C685, A0A164SDM9
D	Beta sliding CLAMP,DNA mismatch repair protein mutl	protein	439	22% helix, 41% strand	A0A085C685, A0A164SDM9

Ligands and binding sites

GOL · Glycerol · additive · 3 copies · chains A, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

18 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	721	0.75	0.80	84	empty
2	235	0.58	0.79	43	empty
3	295	0.57	0.77	35	empty
4	90	0.55	0.85	22	empty
5	141	0.55	0.81	22	empty

Interfaces

4 interfaces between chains.

B–D · 1253 Å² buried · 19 hydrogen bonds · protein-protein
A–C · 1219 Å² buried · 19 hydrogen bonds · protein-protein
B–C · 613 Å² buried · 5 hydrogen bonds · protein-protein
A–B · 283 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

6E8D · Crystal structure of the Bacillus subtilis sliding clamp-MutL complex. · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A085C685
Every structure of UniProt A0A164SDM9
Elsewhere: RCSB PDB 6E8D · PDBe 6E8D · UniProt A0A085C685 · UniProt A0A164SDM9

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