Research workbench
Crystal structure of malaria transmission-blocking antibody TB31F
Analyse Crystal structure of malaria transmission-blocking antibody TB31F in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6E65
- Type
- protein
- Length
- 434 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TB31F Fab light chain; TB31F Fab heavy chain
- Pockets
- 5 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 10% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | TB31F Fab light chain | protein | 214 | 9% helix, 50% strand | — |
| H | TB31F Fab heavy chain | protein | 220 | 11% helix, 52% strand | — |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 511 | 0.61 | 0.74 | 51 | empty |
| 2 | 93 | 0.43 | 0.79 | 24 | empty |
| 3 | 92 | 0.36 | 0.75 | 23 | empty |
| 4 | 80 | 0.33 | 0.74 | 22 | empty |
| 5 | 76 | 0.30 | 0.73 | 24 | empty |
Interfaces
1 interface between chains.
- L–H · 1902 Ų buried · 18 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6E65 · Crystal structure of malaria transmission-blocking antibody TB31F · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6E65 · PDBe 6E65
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