Research workbench
Crystal structure of the mRNA export receptor NXF1/NXT1 in complex with influenza virus NS1 protein
Analyse Crystal structure of the mRNA export receptor NXF1/NXT1 in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6E5U
- Type
- protein
- Length
- 2,576 residues
- Chains
- 16
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nuclear RNA export factor 1; NTF2-related export protein 1; Non-structural protein 1
- UniProt
- Q9UBU9, Q9UKK6, I7CAR2
- Pockets
- 20 · best druggability 0.79
Structure
x-ray diffraction · 6 distinct chains · 35% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E, G | Nuclear RNA export factor 1 | protein | 339 | 31% helix, 24% strand | Q9UBU9 |
| B, D, F, H | NTF2-related export protein 1 | protein | 138 | 30% helix, 46% strand | Q9UKK6 |
| K, M | Non-structural protein 1 | protein | 71 | 83% helix, 0% strand | I7CAR2 |
| L, J | Non-structural protein 1 | protein | 38 | 79% helix, 0% strand | I7CAR2 |
| U, X | Non-structural protein 1 | protein | 115 | 21% helix, 35% strand | I7CAR2 |
| V, Y | Non-structural protein 1 | protein | 110 | 22% helix, 25% strand | I7CAR2 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 209 | 0.79 | 0.92 | 34 | empty |
| 2 | 97 | 0.77 | 0.97 | 27 | empty |
| 3 | 278 | 0.76 | 0.88 | 48 | empty |
| 4 | 201 | 0.75 | 0.90 | 37 | empty |
| 5 | 225 | 0.72 | 0.88 | 43 | empty |
Interfaces
25 interfaces between chains.
- E–F · 2308 Ų buried · 32 hydrogen bonds · protein-protein
- G–H · 2290 Ų buried · 35 hydrogen bonds · protein-protein
- A–B · 2282 Ų buried · 31 hydrogen bonds · protein-protein
- C–D · 2264 Ų buried · 35 hydrogen bonds · protein-protein
- E–H · 1116 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 6E5U · Crystal structure of the mRNA export receptor NXF1/NXT1 in complex with influenza virus… · the same entry in another collection · chain J against J, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UBU9
- Every structure of UniProt Q9UKK6
- Every structure of UniProt I7CAR2
- Elsewhere: RCSB PDB 6E5U · PDBe 6E5U · UniProt Q9UBU9 · UniProt Q9UKK6 · UniProt I7CAR2
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