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Rat procathepsin B

Analyse Rat procathepsin B in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1MIR
Type: protein
Length: 626 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Procathepsin B
EC: 3.4.22.1
UniProt: P00787
Pockets: 2 · best druggability 0.42

Structure

x-ray diffraction · 1 distinct chain · 29% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Procathepsin B (EC 3.4.22.1)	protein	313	29% helix, 23% strand	P00787

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	110	0.42	0.76	17	empty
2	99	0.40	0.76	17	empty

Modifications

Observed in the structure: 12 disulfide (disulfide).

Compared structures

1MIR · Rat procathepsin B · the same entry in another collection · chain B against B, TM-score 1.00
P00787 · AlphaFold monomer V2.0 prediction for cathepsin B (P00787) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00787
Elsewhere: RCSB PDB 1MIR · PDBe 1MIR · UniProt P00787

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