Research workbench
Crystal structure of chlamydomonas reinhardtii HAP2 ectodomain provides structural insights of functional loops in green algae.
Analyse Crystal structure of chlamydomonas reinhardtii HAP2 ectodomain provides… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6E18
- Type
- protein
- Length
- 529 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hapless 2
- UniProt
- A4GRC6
- Ligands
- NAG, MAN, FUC
- Pockets
- 6 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 9% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hapless 2 | protein | 529 | 9% helix, 39% strand | A4GRC6 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 6 copies · chains A
- MAN · alpha-D-mannopyranose · sugar
- FUC · alpha-L-fucopyranose · sugar · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 298 | 0.69 | 0.83 | 29 | empty |
| 2 | 264 | 0.59 | 0.79 | 31 | GOL |
| 3 | 159 | 0.48 | 0.77 | 22 | empty |
| 4 | 122 | 0.42 | 0.75 | 26 | empty |
| 5 | 111 | 0.41 | 0.77 | 25 | empty |
Modifications
Observed in the structure: 11 disulfide, 4 glycan (disulfide, N-glycosylation).
Compared structures
- 6E18 · Crystal structure of Chlamydomonas reinhardtii HAP2 ectodomain provides structural… · the same entry in another collection · chain A against A, TM-score 1.00
- A4GRC6 · AlphaFold monomer V2.0 prediction for hapless 2 (A4GRC6) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A4GRC6
- Elsewhere: RCSB PDB 6E18 · PDBe 6E18 · UniProt A4GRC6
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