Research workbench
Crystal structure of chalcone synthase from arabidopsis thaliana
Analyse Crystal structure of chalcone synthase from arabidopsis thaliana in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6DXB
- Type
- protein
- Length
- 1,554 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chalcone synthase
- EC
- 2.3.1.74
- UniProt
- P13114
- Pockets
- 15 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Chalcone synthase (EC 2.3.1.74) | protein | 389 | 45% helix, 23% strand | P13114 |
| C, D | Chalcone synthase (EC 2.3.1.74) | protein | 388 | 46% helix, 23% strand | P13114 |
Pockets
15 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 131 | 0.79 | 0.97 | 37 | empty |
| 2 | 114 | 0.78 | 0.97 | 31 | empty |
| 3 | 125 | 0.78 | 0.96 | 35 | empty |
| 4 | 873 | 0.74 | 0.78 | 95 | empty |
| 5 | 253 | 0.65 | 0.82 | 29 | empty |
Interfaces
5 interfaces between chains.
- A–C · 3014 Ų buried · 71 hydrogen bonds · protein-protein
- B–D · 3001 Ų buried · 77 hydrogen bonds · protein-protein
- A–D · 243 Ų buried · 0 hydrogen bonds · protein-protein
- C–D · 103 Ų buried · 2 hydrogen bonds · protein-protein
- A–B · 56 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified (oxidation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13114
- Elsewhere: RCSB PDB 6DXB · PDBe 6DXB · UniProt P13114
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