Research workbench
Crystal structure of chalcone synthase from physcomitrella patens
Analyse Crystal structure of chalcone synthase from physcomitrella patens in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6DX7
- Type
- protein
- Length
- 2,322 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chalcone synthase
- EC
- 2.3.1.74
- UniProt
- Q2VAZ3
- Pockets
- 20 · best druggability 0.87
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Chalcone synthase (EC 2.3.1.74) | protein | 387 | 39% helix, 22% strand | Q2VAZ3 |
Pockets
20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1100 | 0.87 | 0.88 | 120 | empty |
| 2 | 1127 | 0.85 | 0.86 | 120 | empty |
| 3 | 1084 | 0.84 | 0.85 | 108 | empty |
| 4 | 375 | 0.78 | 0.87 | 55 | empty |
| 5 | 308 | 0.74 | 0.86 | 46 | empty |
Interfaces
8 interfaces between chains.
- A–B · 3095 Ų buried · 67 hydrogen bonds · protein-protein
- E–F · 3092 Ų buried · 71 hydrogen bonds · protein-protein
- A–D · 702 Ų buried · 8 hydrogen bonds · protein-protein
- B–F · 669 Ų buried · 3 hydrogen bonds · protein-protein
- C–E · 653 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 6DX7 · Crystal structure of chalcone synthase from Physcomitrella patens · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q2VAZ3
- Elsewhere: RCSB PDB 6DX7 · PDBe 6DX7 · UniProt Q2VAZ3
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