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Crystal structure of the viral otu domain protease from dera ghazi khan virus

Analyse Crystal structure of the viral otu domain protease from dera ghazi khan virus in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
6DX2
Type
protein
Length
312 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
RNA-dependent RNA polymerase
UniProt
A0A191KW82
Pockets
5 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 24% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
A, BRNA-dependent RNA polymeraseprotein15640% helix, 24% strandA0A191KW82

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
12080.750.9029empty
21210.490.8032empty
3700.430.8014empty
4650.410.8013empty
5680.330.7519empty

Interfaces

1 interface between chains.

  • A–B · 853 Ų buried · 5 hydrogen bonds · protein-protein

Compared structures

  • 6DX2 · Crystal structure of the viral OTU domain protease from Dera Ghazi Khan virus · the same entry in another collection · chain A against A, TM-score 1.00

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