Research workbench
DHD15_CLOSED
Analyse DHD15_CLOSED in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6DMA
- Type
- protein
- Length
- 560 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DHD15_CLOSED_A; DHD15_CLOSED_B
- Pockets
- 11 · best druggability 0.73
Structure
x-ray diffraction · 8 distinct chains · 93% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DHD15_CLOSED_A | protein | 71 | 94% helix, 0% strand | — |
| B | DHD15_CLOSED_B | protein | 74 | 86% helix, 0% strand | — |
| C | DHD15_CLOSED_A | protein | 73 | 90% helix, 0% strand | — |
| D | DHD15_CLOSED_B | protein | 68 | 94% helix, 0% strand | — |
| E | DHD15_CLOSED_A | protein | 71 | 94% helix, 0% strand | — |
| F | DHD15_CLOSED_B | protein | 69 | 94% helix, 0% strand | — |
| G | DHD15_CLOSED_A | protein | 71 | 94% helix, 0% strand | — |
| H | DHD15_CLOSED_B | protein | 63 | 92% helix, 0% strand | — |
Pockets
11 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 501 | 0.73 | 0.82 | 82 | empty |
| 2 | 210 | 0.61 | 0.82 | 41 | empty |
| 3 | 125 | 0.60 | 0.85 | 28 | empty |
| 4 | 229 | 0.59 | 0.80 | 33 | empty |
| 5 | 154 | 0.58 | 0.82 | 28 | empty |
Interfaces
14 interfaces between chains.
- A–B · 1239 Ų buried · 3 hydrogen bonds · protein-protein
- C–D · 1066 Ų buried · 5 hydrogen bonds · protein-protein
- E–F · 897 Ų buried · 1 hydrogen bond · protein-protein
- G–H · 767 Ų buried · 0 hydrogen bonds · protein-protein
- B–D · 237 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 6DMA · DHD15_closed · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6DMA · PDBe 6DMA
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