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Structure of hnrnp H QRRM1,2

Analyse Structure of hnrnp H QRRM1,2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6DHS
Type: protein
Length: 697 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Heterogeneous nuclear ribonucleoprotein H
UniProt: P31943
Pockets: 9 · best druggability 0.77

Structure

x-ray diffraction · 3 distinct chains · 23% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, D	Heterogeneous nuclear ribonucleoprotein H	protein	174	22% helix, 26% strand	P31943
B	Heterogeneous nuclear ribonucleoprotein H	protein	176	22% helix, 24% strand	P31943
C	Heterogeneous nuclear ribonucleoprotein H	protein	173	24% helix, 21% strand	P31943

Pockets

9 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	973	0.77	0.79	110	empty
2	1113	0.76	0.78	98	empty
3	107	0.75	0.95	37	empty
4	634	0.72	0.79	79	empty
5	91	0.65	0.90	28	empty

Interfaces

3 interfaces between chains.

A–B · 1185 Å² buried · 17 hydrogen bonds · protein-protein
C–D · 1101 Å² buried · 7 hydrogen bonds · protein-protein
A–D · 66 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 modified (engineered).

Compared structures

6DHS · Structure of hnRNP H qRRM1,2 · the same entry in another collection · chain A against A, TM-score 1.00
P31943 · AlphaFold monomer V2.0 prediction for heterogeneous nuclear ribonucleoprotein H (P31943) · a predicted model of the same protein · chain C against A, TM-score 0.52

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P31943
Elsewhere: RCSB PDB 6DHS · PDBe 6DHS · UniProt P31943

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