Research workbench
Crystal structure of anti-zika antibody Z021 bound to zika virus envelope protein diii
Analyse Crystal structure of anti-zika antibody Z021 bound to zika virus envelope… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6DFI
- Type
- protein
- Length
- 537 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Anti-zika antibody Z021, heavy chain; Anti-zika antibody Z021, light chain; Zika virus…
- UniProt
- A0A172HA03
- Pockets
- 6 · best druggability 0.57
Structure
x-ray diffraction · 3 distinct chains · 5% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Anti-zika antibody Z021, heavy chain | protein | 220 | 7% helix, 52% strand | — |
| L | Anti-zika antibody Z021, light chain | protein | 215 | 6% helix, 52% strand | — |
| E | Zika virus envelope protein diii | protein | 102 | 0% helix, 45% strand | A0A172HA03 |
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 437 | 0.57 | 0.74 | 55 | empty |
| 2 | 56 | 0.44 | 0.84 | 23 | empty |
| 3 | 139 | 0.40 | 0.74 | 32 | empty |
| 4 | 117 | 0.36 | 0.73 | 20 | empty |
| 5 | 100 | 0.35 | 0.74 | 22 | empty |
Interfaces
3 interfaces between chains.
- H–L · 2062 Ų buried · 21 hydrogen bonds · protein-protein
- H–E · 463 Ų buried · 7 hydrogen bonds · protein-protein
- L–E · 423 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 6DFI · Crystal structure of anti-Zika antibody Z021 bound to Zika virus envelope protein DIII · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A172HA03
- Elsewhere: RCSB PDB 6DFI · PDBe 6DFI · UniProt A0A172HA03
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