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Crystal structure of the C-terminal arm domain of homo sapiens SPIN90 (SH3-protein interacting with nck), residues 351-722

Analyse Crystal structure of the C-terminal arm domain of homo sapiens SPIN90… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6DED
Type: protein
Length: 680 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nck-interacting protein with SH3 domain
UniProt: Q9NZQ3
Pockets: 1 · best druggability 0.76

Structure

x-ray diffraction · 2 distinct chains · 71% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nck-interacting protein with SH3 domain	protein	336	71% helix, 0% strand	Q9NZQ3
B	Nck-interacting protein with SH3 domain	protein	344	70% helix, 1% strand	Q9NZQ3

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	997	0.76	0.79	89	empty

Interfaces

1 interface between chains.

A–B · 588 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

6DED · Crystal structure of the C-terminal ARM domain of Homo sapiens SPIN90 (SH3-protein… · the same entry in another collection · chain A against A, TM-score 1.00
Q9NZQ3 · AlphaFold monomer V2.0 prediction for nck-interacting protein with SH3 domain (Q9NZQ3) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NZQ3
Elsewhere: RCSB PDB 6DED · PDBe 6DED · UniProt Q9NZQ3

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