Research workbench
Structure of cysz, a sulfate permease from pseudomonas denitrificans
Analyse Structure of cysz, a sulfate permease from pseudomonas denitrificans in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6D9Z
- Type
- protein
- Length
- 1,433 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sulfate transporter cysz
- UniProt
- M4XKU7
- Pockets
- 20 · best druggability 0.84
Structure
x-ray diffraction · 3 distinct chains · 81% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| F, D, E | Sulfate transporter cysz | protein | 240 | 80% helix, 0% strand | M4XKU7 |
| A, B | Sulfate transporter cysz | protein | 236 | 82% helix, 0% strand | M4XKU7 |
| C | Sulfate transporter cysz | protein | 241 | 81% helix, 0% strand | M4XKU7 |
Ligands and binding sites
- BOG · octyl beta-D-glucopyranoside · additive · 20 copies · chains F, A, D, B, C, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 885 | 0.84 | 0.85 | 94 | BOG |
| 2 | 806 | 0.82 | 0.84 | 98 | BOG |
| 3 | 823 | 0.80 | 0.82 | 66 | BOG |
| 4 | 726 | 0.78 | 0.82 | 70 | BOG |
| 5 | 314 | 0.70 | 0.82 | 39 | empty |
Interfaces
12 interfaces between chains.
- C–E · 747 Ų buried · 2 hydrogen bonds · protein-protein
- D–E · 721 Ų buried · 0 hydrogen bonds · protein-protein
- A–B · 715 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 712 Ų buried · 0 hydrogen bonds · protein-protein
- F–A · 693 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6D9Z · Structure of CysZ, a sulfate permease from Pseudomonas Denitrificans · the same entry in another collection · chain F against F, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt M4XKU7
- Elsewhere: RCSB PDB 6D9Z · PDBe 6D9Z · UniProt M4XKU7
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