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Group I self-splicing intron P4-P6 domain mutant G134A/U185AA

Analyse Group I self-splicing intron P4-P6 domain mutant G134A/U185AA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
6D8N
Type
RNA
Length
318 nucleotides
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Group I self-splicing intron
Ligands
MG
Pockets
12 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain.

ChainMoleculeTypeResiduesSecondary structureUniProt
A, BGroup I self-splicing intronrna159——

Ligands and binding sites

  • MG · Magnesium ion · metal · 9 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

12 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
16050.760.8445empty
25710.740.8344MG
34160.710.8323empty
46210.710.8044empty
53650.690.8335MG

Interfaces

1 interface between chains.

  • A–B · 1004 Ų buried · 26 hydrogen bonds · nucleic-nucleic

Compared structures

  • 6D8N · Group I self-splicing intron P4-P6 domain mutant G134A/U185AA · the same entry in another collection · chain A against A, TM-score 1.00

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