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Rabgap domain of human TBC1D22B

Analyse Rabgap domain of human TBC1D22B in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6D0S
Type: protein
Length: 284 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: TBC1 domain family member 22B
UniProt: Q9NU19
Ligands: UNX, SO4
Pockets: 2 · best druggability 0.45

Structure

x-ray diffraction · 1 distinct chain · 69% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	TBC1 domain family member 22B	protein	284	69% helix, 0% strand	Q9NU19

Ligands and binding sites

UNX · Unknown atom or ion · ion · 10 copies · chains A
SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	93	0.45	0.80	21	UNX
2	64	0.34	0.77	16	empty

Compared structures

6D0S · RabGAP domain of human TBC1D22B · the same entry in another collection · chain A against A, TM-score 1.00
Q9NU19 · AlphaFold monomer V2.0 prediction for TBC1 domain family member 22B (Q9NU19) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NU19
Elsewhere: RCSB PDB 6D0S · PDBe 6D0S · UniProt Q9NU19

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