Research workbench
Mycobacterial homoserine kinase thrb in complex with amppnp
Analyse Mycobacterial homoserine kinase thrb in complex with amppnp in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6CYZ
- Type
- protein
- Length
- 590 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Homoserine kinase
- EC
- 2.7.1.39
- UniProt
- B1MLU6
- Ligands
- ANP, CL
- Pockets
- 6 · best druggability 0.58
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Homoserine kinase (EC 2.7.1.39) | protein | 295 | 35% helix, 29% strand | B1MLU6 |
Ligands and binding sites
- ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · 2 copies · chains A, B
- CL · Chloride ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 265 | 0.58 | 0.79 | 42 | ANP |
| 2 | 65 | 0.47 | 0.84 | 17 | ANP |
| 3 | 173 | 0.44 | 0.75 | 31 | ANP |
| 4 | 92 | 0.42 | 0.79 | 19 | empty |
| 5 | 72 | 0.39 | 0.79 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1411 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B1MLU6
- Elsewhere: RCSB PDB 6CYZ · PDBe 6CYZ · UniProt B1MLU6
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.