Research workbench
Crystal structure of a yeast saga transcriptional coactivator ADA2/GCN5 hat subcomplex, crystal form 2
Analyse Crystal structure of a yeast saga transcriptional coactivator ADA2/GCN5 hat… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6CW3
- Type
- protein
- Length
- 1,470 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Antibody heavy chain; Antibody light chain; Histone acetyltransferase GCN5…
- EC
- 2.3.1.48
- UniProt
- Q03330, Q02336
- Ligands
- ZN
- Pockets
- 20 · best druggability 0.77
Structure
x-ray diffraction · 7 distinct chains · 20% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Antibody heavy chain | protein | 222 | 8% helix, 50% strand | — |
| B, D | Antibody light chain | protein | 213 | 7% helix, 49% strand | — |
| C | Antibody heavy chain | protein | 220 | 8% helix, 51% strand | — |
| F | Histone acetyltransferase GCN5 (EC 2.3.1.48) | protein | 199 | 40% helix, 22% strand | Q03330 |
| E | Transcriptional adapter 2 | protein | 120 | 33% helix, 10% strand | Q02336 |
| H | Histone acetyltransferase GCN5 (EC 2.3.1.48) | protein | 191 | 37% helix, 21% strand | Q03330 |
| G | Transcriptional adapter 2 | protein | 92 | 15% helix, 14% strand | Q02336 |
Ligands and binding sites
- ZN · Zinc ion · metal · 4 copies · chains E, G
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 521 | 0.77 | 0.85 | 76 | empty |
| 2 | 242 | 0.66 | 0.83 | 42 | empty |
| 3 | 50 | 0.65 | 0.95 | 18 | empty |
| 4 | 122 | 0.64 | 0.88 | 28 | empty |
| 5 | 367 | 0.64 | 0.79 | 46 | empty |
Interfaces
14 interfaces between chains.
- C–D · 2218 Ų buried · 27 hydrogen bonds · protein-protein
- A–B · 2150 Ų buried · 24 hydrogen bonds · protein-protein
- F–E · 2143 Ų buried · 21 hydrogen bonds · protein-protein
- H–G · 1760 Ų buried · 16 hydrogen bonds · protein-protein
- B–D · 1530 Ų buried · 22 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 6CW3 · Crystal structure of a yeast SAGA transcriptional coactivator Ada2/Gcn5 HAT subcomplex… · the same entry in another collection · chain G against G, TM-score 1.00
- Q02336 · AlphaFold monomer V2.0 prediction for transcriptional adapter 2 (Q02336) · a predicted model of the same protein · chain E against A, TM-score 0.98
- Q03330 · AlphaFold monomer V2.0 prediction for histone acetyltransferase GCN5 (Q03330) · a predicted model of the same protein · chain F against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q03330
- Every structure of UniProt Q02336
- Elsewhere: RCSB PDB 6CW3 · PDBe 6CW3 · UniProt Q03330 · UniProt Q02336
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.