Research workbench
Apo-calmodulin bound to calcium voltage gated channel 1.2 iq-motif
Analyse Apo-calmodulin bound to calcium voltage gated channel 1.2 iq-motif in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6CTB
- Type
- protein
- Length
- 92 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calmodulin-1; Voltage-dependent L-type calcium channel subunit alpha-1C
- UniProt
- P0DP33, P15381
- Pockets
- 1 · best druggability 0.70
Structure
solution nmr · 2 distinct chains · 50% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calmodulin-1 | protein | 67 | 42% helix, 9% strand | P0DP33 |
| B | Voltage-dependent L-type calcium channel subunit alpha-1C | protein | 25 | 72% helix, 0% strand | P15381 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 58 | 0.70 | 0.96 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 1021 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 6CTB · Apo-Calmodulin Bound to Calcium Voltage Gated Channel 1.2 IQ-Motif · the same entry in another collection · chain A against A, TM-score 1.00
- P15381 · AlphaFold monomer V2.0 prediction for voltage-dependent L-type calcium channel subunit… · a predicted model of the same protein · chain B against A, TM-score 0.71
- P0DP33 · AlphaFold monomer V2.0 prediction for calmodulin-1 (P0DP33) · a predicted model of the same protein · chain A against A, TM-score 0.59
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0DP33
- Every structure of UniProt P15381
- Elsewhere: RCSB PDB 6CTB · PDBe 6CTB · UniProt P0DP33 · UniProt P15381
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