Research workbench
Cryoem structure of human enterovirus D68 a-particle (pH 5.5 and room temperature)
Analyse Cryoem structure of human enterovirus D68 a-particle (pH 5.5 and room… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6CS6
- Type
- protein
- Length
- 685 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Viral protein 1; Viral protein 3; Viral protein 2
- UniProt
- A0A097BW12, A0A1I9KXX3
- Pockets
- 6 · best druggability 0.69
Structure
electron microscopy · 3 distinct chains · 9% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Viral protein 1 | protein | 212 | 7% helix, 40% strand | A0A097BW12 |
| B | Viral protein 3 | protein | 240 | 9% helix, 36% strand | A0A097BW12 |
| C | Viral protein 2 | protein | 233 | 12% helix, 36% strand | A0A1I9KXX3 |
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 274 | 0.69 | 0.84 | 34 | empty |
| 2 | 163 | 0.45 | 0.75 | 27 | empty |
| 3 | 93 | 0.37 | 0.76 | 20 | empty |
| 4 | 79 | 0.35 | 0.76 | 19 | empty |
| 5 | 72 | 0.31 | 0.74 | 16 | empty |
Interfaces
3 interfaces between chains.
- A–B · 3301 Ų buried · 50 hydrogen bonds · protein-protein
- B–C · 1798 Ų buried · 15 hydrogen bonds · protein-protein
- A–C · 1720 Ų buried · 36 hydrogen bonds · protein-protein
Compared structures
- 6CS6 · CryoEM structure of human enterovirus D68 A-particle (pH 5.5 and room temperature) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A097BW12
- Every structure of UniProt A0A1I9KXX3
- Elsewhere: RCSB PDB 6CS6 · PDBe 6CS6 · UniProt A0A097BW12 · UniProt A0A1I9KXX3
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