Research workbench
Cryoem structure of human enterovirus D68 expanded 1 particle (pH 7.2 and 4 degrees celsius)
Analyse Cryoem structure of human enterovirus D68 expanded 1 particle (pH 7.2 and 4… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6CS3
- Type
- protein
- Length
- 768 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Viral protein 1; Viral protein 3; Viral protein 2; Viral protein 4
- UniProt
- A0A097BW12, A0A1I9KXX3, A0A191Z5D5
- Pockets
- 13 · best druggability 0.60
Structure
electron microscopy · 4 distinct chains · 9% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Viral protein 1 | protein | 267 | 7% helix, 33% strand | A0A097BW12 |
| B | Viral protein 3 | protein | 240 | 9% helix, 31% strand | A0A097BW12 |
| C | Viral protein 2 | protein | 233 | 10% helix, 35% strand | A0A1I9KXX3 |
| D | Viral protein 4 | protein | 28 | 21% helix, 11% strand | A0A191Z5D5 |
Pockets
13 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 211 | 0.60 | 0.81 | 26 | empty |
| 2 | 133 | 0.48 | 0.78 | 24 | empty |
| 3 | 112 | 0.45 | 0.78 | 23 | empty |
| 4 | 84 | 0.41 | 0.79 | 20 | empty |
| 5 | 162 | 0.41 | 0.73 | 18 | empty |
Interfaces
6 interfaces between chains.
- A–B · 4193 Ų buried · 71 hydrogen bonds · protein-protein
- A–C · 2138 Ų buried · 41 hydrogen bonds · protein-protein
- B–C · 1827 Ų buried · 21 hydrogen bonds · protein-protein
- A–D · 939 Ų buried · 13 hydrogen bonds · protein-protein
- B–D · 849 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 6CS3 · CryoEM structure of human enterovirus D68 expanded 1 particle (pH 7.2 and 4 degrees… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A097BW12
- Every structure of UniProt A0A1I9KXX3
- Every structure of UniProt A0A191Z5D5
- Elsewhere: RCSB PDB 6CS3 · PDBe 6CS3 · UniProt A0A097BW12 · UniProt A0A1I9KXX3 · UniProt A0A191Z5D5
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