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ARG65GLN mutagenic E.COLI pck

Analyse ARG65GLN mutagenic E.COLI pck in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6CRT
Type: protein
Length: 531 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Phosphoenolpyruvate carboxykinase (ATP)
EC: 4.1.1.49
UniProt: B7L4T1
Ligands: ATP, MN
Pockets: 3 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 33% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Phosphoenolpyruvate carboxykinase (ATP) (EC 4.1.1.49)	protein	531	33% helix, 24% strand	B7L4T1

Ligands and binding sites

ATP · Adenosine-5'-triphosphate · ligand · chains A
MN · Manganese (II) ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	728	0.73	0.79	78	ATP, MN
2	106	0.41	0.76	20	empty
3	51	0.32	0.77	12	empty

Compared structures

6CRT · Arg65Gln Mutagenic E.coli PCK · the same entry in another collection · chain A against A, TM-score 1.00
B7L4T1 · AlphaFold monomer V2.0 prediction for phosphoenolpyruvate carboxykinase (ATP) (B7L4T1) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B7L4T1
Elsewhere: RCSB PDB 6CRT · PDBe 6CRT · UniProt B7L4T1

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