Research workbench
Crystal structure of lambda-cro bound to a consensus operator at 3.0 ångström resolution
Analyse Crystal structure of lambda-cro bound to a consensus operator at 3.0 ångström… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6CRO
- Type
- protein + DNA
- Length
- 100 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA (5'- D(*AP*CP*TP*AP*TP*CP*AP*CP*CP*GP*CP*GP*GP*GP*TP*GP*AP*TP*AP*C)-3'); DNA (5'…
- UniProt
- P03040
- Ligands
- SO4
- Pockets
- 1 · best druggability 0.41
Structure
x-ray diffraction · 3 distinct chains · 43% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| R | DNA (5'- D(*AP*CP*TP*AP*TP*CP*AP*CP*CP*GP*CP*GP*GP*GP*TP*GP*AP*TP*AP*C)-3') | dna | 20 | — | — |
| U | DNA (5'- D(*TP*GP*TP*AP*TP*CP*AP*CP*CP*CP*GP*CP*GP*GP*TP*GP*AP*TP*AP*G)-3') | dna | 20 | — | — |
| A | Lambda cro repressor | protein | 60 | 43% helix, 25% strand | P03040 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 72 | 0.41 | 0.80 | 15 | empty |
Interfaces
3 interfaces between chains.
- R–A · 700 Ų buried · 18 hydrogen bonds · protein-nucleic
- U–A · 697 Ų buried · 19 hydrogen bonds · protein-nucleic
- R–U · 294 Ų buried · 375 hydrogen bonds · nucleic-nucleic
Compared structures
- 6CRO · Crystal structure of lambda-cro bound to a consensus operator at 3.0 ångström resolution · the same entry in another collection · chain R against R, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03040
- Elsewhere: RCSB PDB 6CRO · PDBe 6CRO · UniProt P03040
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