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Co-crystal structure of HIV-1 tar bound to lab-evolved rrm TBP6.7
Analyse Co-crystal structure of HIV-1 tar bound to lab-evolved rrm TBP6.7 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6CMN
- Type
- protein + RNA
- Length
- 118 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tar-binding protein 6.7; Trans-activation response RNA element
- UniProt
- G1TM83
- Pockets
- 2 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 29% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tar-binding protein 6.7 | protein | 91 | 29% helix, 25% strand | G1TM83 |
| D | Trans-activation response RNA element | rna | 27 | — | — |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 166 | 0.68 | 0.87 | 24 | empty |
| 2 | 299 | 0.52 | 0.75 | 27 | empty |
Interfaces
1 interface between chains.
- A–D · 773 Ų buried · 20 hydrogen bonds · protein-nucleic
Compared structures
- 6CMN · Co-Crystal Structure of HIV-1 TAR Bound to Lab-Evolved RRM TBP6.7 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G1TM83
- Elsewhere: RCSB PDB 6CMN · PDBe 6CMN · UniProt G1TM83
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