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High resolution crystal structure of the hemagglutinin H1 head domain of influenza a virus solomon islands

Analyse High resolution crystal structure of the hemagglutinin H1 head domain of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6CHX
Type: protein
Length: 420 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hemagglutinin
UniProt: D1MNG6
Pockets: 5 · best druggability 0.58

Structure

x-ray diffraction · 2 distinct chains · 13% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hemagglutinin	protein	214	13% helix, 35% strand	D1MNG6
B	Hemagglutinin	protein	206	14% helix, 39% strand	D1MNG6

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	100	0.58	0.86	34	empty
2	87	0.43	0.79	17	empty
3	94	0.40	0.77	18	empty
4	70	0.39	0.80	20	empty
5	85	0.35	0.75	18	empty

Interfaces

1 interface between chains.

A–B · 864 Å² buried · 12 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

6CHX · High Resolution Crystal Structure of the Hemagglutinin H1 Head Domain of Influenza A… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt D1MNG6
Elsewhere: RCSB PDB 6CHX · PDBe 6CHX · UniProt D1MNG6

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