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Crystal structure of fragment 3-(3-methyl-4-oxo-3,4-dihydroquinazolin- 2-YL)PROPANOIC acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain

Analyse Crystal structure of fragment 3-(3-methyl-4-oxo-3,4-dihydroquinazolin… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6CED
Type: protein
Length: 99 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Histone deacetylase 6
EC: 3.5.1.98
UniProt: Q9UBN7
Ligands: EYA, ZN, UNX

Structure

x-ray diffraction · 1 distinct chain · 26% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Histone deacetylase 6 (EC 3.5.1.98)	protein	99	26% helix, 18% strand	Q9UBN7

Ligands and binding sites

EYA · 3-(3-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)propanoic acid · ligand · chains A
ZN · Zinc ion · metal · 3 copies · chains A
UNX · Unknown atom or ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6CED · Crystal structure of fragment 3-(3-Methyl-4-oxo-3,4-dihydroquinazolin-2-yl)propanoic acid… · the same entry in another collection · chain A against A, TM-score 1.00
Q9UBN7 · AlphaFold monomer V2.0 prediction for histone deacetylase 6 (Q9UBN7) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UBN7
Elsewhere: RCSB PDB 6CED · PDBe 6CED · UniProt Q9UBN7

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