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Cryoem structure of human SLC4A4 sodium-coupled acid-base transporter NBCE1

Analyse Cryoem structure of human SLC4A4 sodium-coupled acid-base transporter NBCE1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6CAA
Type: protein
Length: 954 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Electrogenic sodium bicarbonate cotransporter 1
UniProt: Q9Y6R1
Pockets: 17 · best druggability 0.72

Structure

electron microscopy · 1 distinct chain · 59% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Electrogenic sodium bicarbonate cotransporter 1	protein	477	59% helix, 1% strand	Q9Y6R1

Pockets

17 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	559	0.72	0.80	52	empty
2	390	0.71	0.82	37	empty
3	259	0.64	0.81	36	empty
4	303	0.63	0.80	44	empty
5	244	0.62	0.81	34	empty

Interfaces

1 interface between chains.

A–B · 1433 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

6CAA · CryoEM structure of human SLC4A4 sodium-coupled acid-base transporter NBCe1 · the same entry in another collection · chain A against A, TM-score 1.00
Q9Y6R1 · AlphaFold monomer V2.0 prediction for electrogenic sodium bicarbonate cotransporter 1… · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Y6R1
Elsewhere: RCSB PDB 6CAA · PDBe 6CAA · UniProt Q9Y6R1

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