Research workbench
Crystal structure of PCT64_13C, a strain specific anti-HIV antibody
Analyse Crystal structure of PCT64_13C, a strain specific anti-HIV antibody in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6CA7
- Type
- protein
- Length
- 446 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- PCT64_13C light chain; PCT64_13C heavy chain
- Pockets
- 4 · best druggability 0.57
Structure
x-ray diffraction · 2 distinct chains · 8% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | PCT64_13C light chain | protein | 213 | 8% helix, 53% strand | — |
| H | PCT64_13C heavy chain | protein | 233 | 8% helix, 51% strand | — |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 144 | 0.57 | 0.82 | 23 | empty |
| 2 | 317 | 0.55 | 0.75 | 43 | empty |
| 3 | 119 | 0.42 | 0.76 | 26 | empty |
| 4 | 68 | 0.29 | 0.73 | 13 | empty |
Interfaces
1 interface between chains.
- L–H · 1787 Ų buried · 18 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide, 1 modified (disulfide, sulfation).
Compared structures
- 6CA7 · Crystal structure of PCT64_13C, a strain specific anti-HIV antibody · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6CA7 · PDBe 6CA7
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