Research workbench
Crystal structure of cysteine desulfurase from legionella pneumophila philadelphia 1
Analyse Crystal structure of cysteine desulfurase from legionella pneumophila… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6C9E
- Type
- protein
- Length
- 811 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cysteine desulfurase
- EC
- 2.8.1.7
- UniProt
- Q5ZXX6
- Ligands
- ZN
- Pockets
- 3 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cysteine desulfurase (EC 2.8.1.7) | protein | 405 | 45% helix, 19% strand | Q5ZXX6 |
| B | Cysteine desulfurase (EC 2.8.1.7) | protein | 406 | 45% helix, 19% strand | Q5ZXX6 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A, B
- EDO · 1,2-ethanediol · additive · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 400 | 0.66 | 0.79 | 43 | empty |
| 2 | 58 | 0.61 | 0.93 | 17 | EDO |
| 3 | 54 | 0.34 | 0.78 | 10 | empty |
Interfaces
1 interface between chains.
- A–B · 3433 Ų buried · 62 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (cofactor).
Compared structures
- 6C9E · Crystal structure of Cysteine desulfurase from Legionella pneumophila Philadelphia 1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5ZXX6
- Elsewhere: RCSB PDB 6C9E · PDBe 6C9E · UniProt Q5ZXX6
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.