Research workbench
Crystal structure of the soluble domain of the mitochondrial calcium uniporter
Analyse Crystal structure of the soluble domain of the mitochondrial calcium uniporter in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6C5R
- Type
- protein
- Length
- 1,244 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calcium uniporter
- UniProt
- E9DVV4
- Pockets
- 20 · best druggability 0.75
Structure
x-ray diffraction · 8 distinct chains · 41% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calcium uniporter | protein | 142 | 48% helix, 20% strand | E9DVV4 |
| B | Calcium uniporter | protein | 139 | 42% helix, 19% strand | E9DVV4 |
| D | Calcium uniporter | protein | 171 | 35% helix, 26% strand | E9DVV4 |
| F | Calcium uniporter | protein | 169 | 34% helix, 25% strand | E9DVV4 |
| H | Calcium uniporter | protein | 170 | 34% helix, 26% strand | E9DVV4 |
| C | Calcium uniporter | protein | 141 | 50% helix, 15% strand | E9DVV4 |
| E | Calcium uniporter | protein | 159 | 45% helix, 22% strand | E9DVV4 |
| G | Calcium uniporter | protein | 153 | 44% helix, 24% strand | E9DVV4 |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 904 | 0.75 | 0.78 | 87 | empty |
| 2 | 1018 | 0.74 | 0.77 | 77 | empty |
| 3 | 416 | 0.73 | 0.83 | 49 | empty |
| 4 | 284 | 0.73 | 0.86 | 27 | empty |
| 5 | 542 | 0.70 | 0.79 | 43 | empty |
Interfaces
18 interfaces between chains.
- D–E · 1783 Ų buried · 5 hydrogen bonds · protein-protein
- F–C · 1761 Ų buried · 8 hydrogen bonds · protein-protein
- A–H · 1677 Ų buried · 4 hydrogen bonds · protein-protein
- B–G · 1589 Ų buried · 4 hydrogen bonds · protein-protein
- F–E · 792 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 6C5R · Crystal structure of the soluble domain of the mitochondrial calcium uniporter · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E9DVV4
- Elsewhere: RCSB PDB 6C5R · PDBe 6C5R · UniProt E9DVV4
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