Research workbench
O2-, plp-dependent L-arginine hydroxylase rohp 4-hydroxy-2- ketoarginine complex
Analyse O2-, plp-dependent L-arginine hydroxylase rohp 4-hydroxy-2- ketoarginine complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6C3A
- Type
- protein
- Length
- 755 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uncharacterized protein
- Ligands
- EGV
- Pockets
- 7 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 52% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Uncharacterized protein | protein | 378 | 52% helix, 14% strand | — |
| B | Uncharacterized protein | protein | 377 | 51% helix, 14% strand | — |
Ligands and binding sites
- EGV · (4S)-5-carbamimidamido-4-hydroxy-2-oxopentanoic acid · ligand · 2 copies · chains A, B
- EDO · 1,2-ethanediol · additive · 11 copies · chains A, B
- PEG · Di(hydroxyethyl)ether · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 61 | 0.75 | 0.99 | 14 | empty |
| 2 | 191 | 0.65 | 0.85 | 28 | empty |
| 3 | 192 | 0.62 | 0.83 | 27 | empty |
| 4 | 171 | 0.55 | 0.80 | 25 | EDO |
| 5 | 155 | 0.50 | 0.78 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 2682 Ų buried · 41 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (cofactor).
Compared structures
- 6C3A · O2-, PLP-dependent L-arginine hydroxylase RohP 4-hydroxy-2-ketoarginine complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6C3A · PDBe 6C3A
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