Research workbench
Mycobacterium smegmatis flap endonuclease mutant D148N
Analyse Mycobacterium smegmatis flap endonuclease mutant D148N in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6C35
- Type
- protein
- Length
- 317 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5'-3' exonuclease
- UniProt
- I7GAS0
- Ligands
- MN
- Pockets
- 3 · best druggability 0.64
Structure
x-ray diffraction · 1 distinct chain · 49% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 5'-3' exonuclease | protein | 317 | 49% helix, 12% strand | I7GAS0 |
Ligands and binding sites
- MN · Manganese (II) ion · metal · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 440 | 0.64 | 0.78 | 43 | MN |
| 2 | 93 | 0.35 | 0.75 | 21 | empty |
| 3 | 58 | 0.33 | 0.77 | 14 | empty |
Compared structures
- 6C35 · Mycobacterium smegmatis flap endonuclease mutant D148N · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt I7GAS0
- Elsewhere: RCSB PDB 6C35 · PDBe 6C35 · UniProt I7GAS0
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