Research workbench
Corynebacterium 2,5-dkgr a and phe 22 replaced with tyr (F22Y), lys 232 replaced with gly (K232G), arg 238 replaced with his (R238H)AND ala 272 replaced with gly (A272G)IN presence of NADH cofactor
Analyse Corynebacterium 2,5-dkgr a and phe 22 replaced with tyr (F22Y), lys 232… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1M9H
- Type
- protein
- Length
- 277 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 2,5-diketo-D-gluconic acid reductase a
- EC
- 1.1.1.-
- UniProt
- P06632
- Ligands
- NAD, SO4
- Pockets
- 1 · best druggability 0.59
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 2,5-diketo-D-gluconic acid reductase a (EC 1.1.1.-) | protein | 277 | 44% helix, 16% strand | P06632 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 256 | 0.59 | 0.79 | 39 | NAD |
Compared structures
- 1M9H · Corynebacterium 2,5-DKGR A and Phe 22 replaced with Tyr (F22Y), Lys 232 replaced with Gly… · the same entry in another collection · chain A against A, TM-score 1.00
- P06632 · AlphaFold monomer V2.0 prediction for 2,5-diketo-D-gluconic acid reductase a (P06632) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06632
- Elsewhere: RCSB PDB 1M9H · PDBe 1M9H · UniProt P06632
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