Research workbench
Glucocorticoid receptor bound to high cooperativity monomer sequence
Analyse Glucocorticoid receptor bound to high cooperativity monomer sequence in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6BSE
- Type
- protein + DNA
- Length
- 177 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glucocorticoid receptor; DNA (5'- D(P*TP*AP*AP*AP*AP*AP*GP*TP*AP*CP*AP*CP*GP*TP*GP*G)-3')…
- UniProt
- P79269
- Ligands
- ZN
- Pockets
- 2 · best druggability 0.68
Structure
x-ray diffraction · 4 distinct chains · 32% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glucocorticoid receptor | protein | 73 | 30% helix, 11% strand | P79269 |
| B | Glucocorticoid receptor | protein | 72 | 33% helix, 11% strand | P79269 |
| C | DNA (5'- D(P*TP*AP*AP*AP*AP*AP*GP*TP*AP*CP*AP*CP*GP*TP*GP*G)-3') | dna | 16 | — | — |
| D | DNA (5'- D(P*AP*CP*CP*AP*CP*GP*TP*GP*TP*AP*CP*TP*TP*TP*TP*T)-3') | dna | 16 | — | — |
Ligands and binding sites
- ZN · Zinc ion · metal · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 480 | 0.68 | 0.79 | 37 | empty |
| 2 | 103 | 0.36 | 0.75 | 19 | empty |
Interfaces
6 interfaces between chains.
- C–D · 679 Ų buried · 62 hydrogen bonds · nucleic-nucleic
- A–B · 613 Ų buried · 9 hydrogen bonds · protein-protein
- A–D · 384 Ų buried · 6 hydrogen bonds · protein-nucleic
- A–C · 320 Ų buried · 5 hydrogen bonds · protein-nucleic
- B–C · 284 Ų buried · 7 hydrogen bonds · protein-nucleic
Compared structures
- 6BSE · Glucocorticoid receptor bound to high cooperativity monomer sequence · the same entry in another collection · chain A against A, TM-score 1.00
- P79269 · AlphaFold monomer V2.0 prediction for glucocorticoid receptor (P79269) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P79269
- Elsewhere: RCSB PDB 6BSE · PDBe 6BSE · UniProt P79269
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.